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Wednesday, December 1, 2021

UN leads bid for cheaper insulin, expanding access for diabetics worldwide

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Overly expensive insulin could be a thing of the past and life-changing news for millions of diabetics under a plan launched by the World Health Organization to diversify production globally.

Announcing the initiative in Geneva just ahead of the World Diabetes Day, the UN agency said that it had already had informal expressions of interest from pharmaceutical companies looking to produce insulin and have WHO assess whether it is safe for people to use.

Emer Cooke, director of the Regulation of Medicines and other Health Technologies at WHO, said that the simple fact is that the prevalence of diabetes is growing, the amount of insulin available to treat diabetes is too low, the prices are too high, so “we need to do something.”

Coinciding with the project launch, which comes ahead of the World Diabetes Day marked each November 14, UN Secretary-General Antonio Guterres highlighted the impact of catastrophic medical expenses on sufferers.

He said that diabetes damages health and undermines educational and employment aspirations for many, affecting communities and forcing families into economic hardship, particularly in low and middle-income countries.

The WHO’s two-year pilot project involves evaluation of insulin developed by manufacturers to ensure their quality, safety, efficacy and affordability. Assuming there is enough interest from manufacturers and, crucially, more insulin available for diabetics, the scheme could be expanded more widely.

“We’re going to look at the number of companies that will apply, we’re going to look at how long it takes, we’re going to look at the outcomes and we’re going to see whether this makes sense and it really is increasing access,” Emer Cooke said.

The procedure is known as prequalification and WHO has done it in the past for non-brand vaccines, including those used to treat TB, malaria and HIV. This had resulted in massive savings for sufferers around the world, with 80 per cent of HIV patients now relying on generic products, she said.

She noted too that some companies had already committed to lowering prices. “When HIV anti-retrovirals were first produced, the cost per patient per year was $10,000,” she said. “Once we opened prequalification for generic HIV products, the price went down to $300 per year.”

She said, “we’re also confident that competition will bring prices down. That way, countries will have a greater choice of products that are more affordable.” Today, three manufacturers control most of the global market for insulin, which was discovered as a treatment for diabetes in 1921.

The medicine works by lowering blood glucose levels, a task that is usually carried out by natural insulin, which is produced by the pancreas whenever we eat. The quadrupling in the number of people with diabetes since 1980 – to around 420 million today, mostly in low and middle-income countries – is widely attributed to poor diet and a lack of exercise.

Those with type one diabetes – around 20 million people – need insulin injections to survive, while only around half of the 65 million type-two sufferers who need insulin are able to get it, WHO said. In some countries, prices are so prohibitive that some people are forced to ration their insulin.

This leaves them susceptible to heart attacks, stroke, kidney failure, blindness and lower limb amputations. And while diabetes was the seventh leading cause of death globally in 2016, the finding is only worrying because the disease kills people prematurely, said Dr Gojka Roglic, WHO medical officer and diabetes expert.

“We all have to die of something and why not of diabetes – but (only) after celebrating our 90th birthday,” she joked. “The problem with diabetes is that it accounts for a large proportion of premature diabetes – almost half of them occur before 70.” In low and middle-income countries, the percentage rises to around 60 per cent, Dr Roglic said.

Data collected by WHO from 24 countries on four continents showed that human insulin was available only in 61 per cent of health facilities.

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Staff Writerhttps://www.thewallet.com.pk
The Wallet Team produces these stories.
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